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J Cutan Pathol. 1999 May;26(5):263-4. Factor XIIIa-positive dendrocytes in malignant melanoma. Piérard-Franchimont C, Piérard GE. Comment on J Cutan Pathol. 1998 Nov;25(10):553-8. Factor XIII, also known as fibrin-stabilizing factor, is a 320-kDa glycoprotein that is the proenzyme for plasma transglutaminase. In plasma, it circulates as a proenzyme consisting of two catalytic A subunits and two noncatalytic B subunits.
Metoda – test de solubilizare a cheagului (se determina cea mai mare dilutie a plasmei la care un cheag, obtinut prin adaugarea de trombina si calciu la un fibrinogen exogen fara factor XIII, ramane insolubil in prezenta acidului cloroacetic) 4. Valori de referinta – 80% -150% 4. Limite si interferente 1 Sep 1998 We show that factor XIIIa (FXIIIa, the potentially active a2‐subunit of factor XIII), an enzyme that participates in blood coagulation by stabilizing Factor XIIIa rapidly cross-links α2-antiplasmin to the α-chain of fibrin.67,68 Invitrogen Human Factor XIIIa Protein, Catalog # RP-43123. Tested in Control ( Ctrl) applications. Supplied as 50 µg purified protein (2.4 mg/mL).
Anti-Blood Coagulation Factor XIIIa Monoclonal Antibody
Cited in 1 reference(s). Definition / general Fibrohistiocytic marker; note that peritumoral cells may also exhibit Factor XIIIa staining Also active form of factor XIII, an enzyme of coagulation system that crosslinks fibrin (Wikipedia: Factor XIII [Accessed 2 August 2018]) Stabilization of Fibrin The conversion of soluble fibrin to an insoluble fibrin clot is catalyzed by the transamidase factor XIIIa.
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Specifications. Specifications Mouse monoclonal Factor XIIIa antibody [AC-1A1]. Validated in WB, IHC, Flow Cyt and tested in Human. Cited in 10 publication(s).
它是一种钙依赖的谷氨酰胺转胺酶或转胺酶，在纤维蛋白分子间形成-谷氨酰胺-爱塞隆-赖氨酸交联，从而使纤维蛋白凝块的机械稳定性及其对蛋白水解的抵抗力。. XIIIa因子也可能起稳定细胞表面分子和细胞膜的作用。. 钙依赖的转谷氨酰胺酶具有巯基活性中心，广泛
Factor XIII a is an enzyme and as a coagulation factor it is an important part of the blood coagulation cascade.
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Factor XIIIa is a blood coagulation prototransglutaminase 1, which becomes an activated component of the final stages of the clotting cascade as a result of the interaction with thrombin and Ca 2+. Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system. Factor XIII deficiency is an extremely rare inherited blood disorder characterized by abnormal blood clotting that may result in abnormal bleeding.
It is equally possible that the factor XIIIa-positive cells are only activated stromal cells. Factor XIIIa (AC‐1A1) is a sensitive and specific nuclear marker for sebaceous differentiation. Its diagnostic utility exceeds that of adipophilin. Factor XIIIa should be included in the expanding group of immunohistochemical and special stains which can be utilized to aid in the diagnosis of sebaceous neoplasms.
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Browse our Factor XIIIa product catalog backed by our Guarantee+. Factorul XIII sau factorul stabilizator al fibrinei este o molecula tetramerica sintetizata la nivelul hepatocitelor si megacariocitelor. Este activat de trombina in prezenta ionilor de Ca. 1 Sep 1998 We show that factor XIIIa (FXIIIa, the potentially active a2‐subunit of factor XIII), an enzyme that participates in blood coagulation by stabilizing 28 Jul 2016 Factor XIIIa (FXIIIa) is a transglutaminase that catalyzes the last step in the coagulation process. Orthostery is the only approach that has been 20 Jan 2011 Transglutaminase activity, arising potentially from transglutaminase 2 (TG2) and Factor XIIIA (FXIIIA), has been linked to osteoblast Factor XIIIa (EP3372) Rabbit Monoclonal Primary Antibody; find Sigma-Aldrich- 251R-1 MSDS, related peer-reviewed papers, technical documents, similar Coagulation factor XIIIa (FXIIIa) is a transglutaminase that covalently cross-links fibrin and other proteins to fibrin to stabilize blood clots and reduce blood loss. FC13A : Factor XIIIa, a blood and intracellularly produced coagulation factor, has been found in a variety of cell types, including fibroblast-like mesenchymal Factor XIIIa has also been used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans (3).